WHAT WE DO · SPHENOPALATINE GANGLION BLOCK
A sphenopalatine ganglion block puts local anesthetic on a nerve cluster behind the nose. It usually goes through the nostril with a fine applicator and no needle. It is used for cluster headache, migraine with autonomic features and some facial pain.
That cluster of nerve cells plays a part in a specific set of head and face pains. The approach is gentler than most people expect when they hear the word block.

What is the sphenopalatine ganglion?
The sphenopalatine ganglion sits in a small space behind the nasal cavity. It carries sensory fibers. It also carries the parasympathetic supply to the nose, palate and lacrimal (tear) gland. That second part is why it matters for headache. The autonomic features of an attack run through it: watering eye, blocked nostril, facial flushing.
It lies just under the lining of the nose. So local anesthetic can reach it through the nostril using a fine applicator. No needle is needed for that approach, which surprises most people.
WHERE IT IS CONSIDERED
- Cluster headache, especially during a bout.
- Migraine with strong autonomic features, or attacks that do not respond to standard acute treatment.
- Some kinds of facial pain.
- As a bridging option while an overuse pattern is unwound, because it adds nothing to the medication-day count.
What happens during a sphenopalatine ganglion block?
- You sit or lie with the head tilted back. A topical anesthetic applicator is passed along the floor of the nostril.
- It stays in place a few minutes on each side.
- A bitter taste and temporary numbness at the back of the throat are usual and settle.
- Nose bleeding is uncommon. The technique is designed to avoid injury.
- Most patients drive themselves home and return to normal activity within two to four hours.
Honest framing of the evidence
The evidence is more modest than for the better-known headache treatments. It is not a first-line option. It is not a substitute for a preventive plan. It has a real place as an add-on in specific cases. That is especially true when whole-body drug exposure is a problem, or when standard acute treatment is failing. It should be offered on that basis, not oversold.
When it does help, the relief may outlast the anesthetic. That points to the same mechanism as elsewhere on this site. Interrupting a steady input lets a sensitized system reset. And the same three factors decide how long that reset holds. They are the metabolic terrain, sleep, and whether the pattern that drove the attacks has changed.
Frequently asked questions
Is it painful?
With the topical approach it is uncomfortable rather than painful. Most people describe pressure and a bitter taste, not pain.
Is it a needle in my face?
Not for the transnasal (through the nose) topical approach, which is the usual one. Other routes exist and are discussed if needed.
How long does it last?
It varies a lot, from hours to weeks. That range is part of why it is an add-on, not a foundation.
Is it better than a nerve block at the back of the head?
Different target for a different picture. Occipital blocks suit sources at the back of the head and neck. This one suits autonomic and facial ones. See the occipital block.
What are the side effects of a sphenopalatine ganglion block?
A bitter taste and temporary numbness at the back of the throat are usual. Both settle. Nose bleeding is uncommon, because the technique is designed to avoid injury to the lining of the nose. Most people describe pressure rather than pain with the topical approach, and most patients drive themselves home afterward.
Does a sphenopalatine ganglion block work?
It has a real place as an add-on in specific cases. Those include cluster headache and migraine with autonomic features. They also include attacks where standard acute treatment is failing or whole-body drug exposure is a problem. It is not a first-line option or a substitute for a preventive plan. When it helps, the relief can outlast the anesthetic. How long it holds depends on the metabolic terrain, sleep and what drove the attacks.
Compare and read on
An adjunct with a real place, offered as one
It is not a first-line treatment and we will not present it as one. Where it fits, it fits well.
12174 Natural Bridge Rd, Suite 304
St. Louis, MO 63044
Next to DePaul Hospital, off the I‑270 and I‑70 junction, west of the airport.
Sources
- Cometa MA et al. Sphenopalatine ganglion block: do not give up on it just yet!. British journal of anaesthesia, 2021. PubMed 33795136
- Murphy CA et al. Sphenopalatine Ganglion Block for Postdural Puncture Headache. Pain medicine (Malden, Mass.), 2020. PubMed 32049339
- Yan Y et al. Transnasal sphenopalatine ganglion block for treating postdural puncture headache: A case report and literature review. Asian journal of surgery, 2024. PubMed 39048437